| Jason Mewes | Jay |
| Kevin Smith | Silent Bob |
| Ben Affleck | Holden McNeil/Himself |
| Jeff Anderson | Randal Graves |
| Brian O'Halloran | Dante Hicks |
| Shannon Elizabeth | Justice |
| Eliza Dushku | Sissy |
| Ali Larter | Chrissy |
| Jennifer Schwalbach Smith | Missy |
| Will Ferrell | Federal Wildlife Marshal Willenholly |
| Jason Lee | Brodie Bruce/Banky Edwards |
| Judd Nelson | Sheriff |
| George Carlin | Hitchhiker |
| Carrie Fisher | Nun |
| Seann William Scott | Brent |
| Jon Stewart | Reg Hartner |
| Jules Asner | Herself |
| Steve Kmetko | Himself |
| Tracy Morgan | Pumpkin Escobar |
| Gus Van Sant | Himself |
| Chris Rock | Chaka Luther King |
| Jamie Kennedy | Chaka's Production Assistant |
| Wes Craven | Himself |
| Shannen Doherty | Herself |
| Mark Hamill | Himself/Talking dog voice |
| Amy Noble | Silent Bob's Mother |
| Harley Quinn Smith | Baby Silent Bob |
| Ever Carradine | Jay's Mother |
| Brian Andrew Saible | Baby Jay |
| Gavin Brooks | Baby Jay |
| John Willyung | Passerby |
| Jake Richardson | Teen #1 |
| Nick Fellinger | Teen #2 |
| Vincent Pereira | Quick Stop Customer |
| Ernest O'Donnell | Cop |
| Marc Blucas | The Guy |
| Matthew James | The Dude |
| Jane Silvia | Bookish Girl |
| Carmen Lee | Redhead beauty |
| Dan Etheridge | Deputy |
| Eric Winzenried | Cop #1 |
| Jonathan Gordon | Cop #2 |
| John Maynard | Cop #3 |
| Robert Holtzman | Cop #4 |
| Tom Dorfmeister | Cop #5 |
| Joe Quesada | Pizza Delivery Guy |
| Michelle Anne Johnson | Hooker #1 |
| Merritt Hicks | Hooker #2 |
| Diedrich Bader | Miramax Security Guard Gordon |
| Scott Mosier | Assistant Director (GWH2)/Willam Black |
| James J. McLauchlin | Clapper/Loader (GWH2) |
| Joseph D. Reitman | Assistant Director (Bluntman & Chronic) |
| Paul Dini | Clapper/Loader (Bluntman & Chronic) |
| Quentin Wright | William Dusky |
| Gregory Owen | Suburban Kid |
| Ralph B. Meyer | Receptionist |
| Bryan Johnson | Steve-Dave Pulasti |
| Walter Flanagan | Walt Grover the Fanboy |
| Renée Humphrey | Tricia Jones |
| Joey Lauren Adams | Alyssa Jones |
| Dwight Ewell | Hooper LaMont |
| Alanis Morissette | That Woman (God) |
| Morris Day | Himself |
| Matt Damon | Himself |
| Cass Franklin | Extra |
| Garry Johnson | Himself |
| Zak Charles Knutson | The C.L.I.T. |
| Steven Anthony Lawrence | The Kid in the Helmet |
| Brian Lynch | Comic Book Shopper #1 |
| David Mandel | Extra |
| Chris McDevitt | Comic Book Shopper #2 |
| Monte Moir | Himself |
| Jerome Benton | Himself |
| Derek Raser | Bus Driver |
| Jason Biggs | Himself |
| Scott C. Sener | Quiet Scott |
| Rusty Sheridan | Afroed Whitey |
| James Van Der Beek | Himself |
| Scott William Winters | Clark/Himself |
| Thomas Burke | Blue Collar Man |
| Adam Carolla | FBI Agent Sid |
| Stephanie Logan | Convenience Store Girl |
| Nicole Vanderhoff | Good Will Hunting II Extra Glaring at PA |
| Susan Engel | Ben Affleck's "behind the scene" make-up artist |
